منابع مشابه
Primary malignant myopericytoma with cancer cachexia
RATIONALE Malignant myopericytoma is extremely rare, with a few cases described in the English literature. PATIENT CONCERNS This novel study aimed to report a case of malignant myopericytoma with cancer cachexia arising in the left armpit. Also, it presented a review of the English literature regarding primary malignant myopericytoma, aiming to clarify the clinical features and potentially cu...
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Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac muscle and increased life span by blocking ActRIIB with a decoy receptor.
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Cancer induced cachexia (CIC) is a syndrome of muscle wasting accompanied by anorexia with or without loss of adipose tissue. Underlying CIC is a complex interaction of proinflammatory cytokines that act centrally on the hypothalamus and peripherally to increase catabolism and resting energy expenditure, while decreasing protein synthesis. The presence of CIC is an important prognostic indicato...
متن کاملCancer Cachexia
Cancer anorexia-cachexia (CACS) is defined as a multifactorial syndrome characterized by ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment [1]. Cancer cachexia occurs across a continuum, varying in severity and stage; according to new classification we have pre-cachexia (early clinical signs of c...
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One of the metabolic hallmarks of sepsis and severe injury is muscle cachexia, mainly reflecting increased protein breakdown, in particular myofibrillar protein breakdown. This review describes recent knowledge regarding the molecular mechanisms of sepsis-induced muscle cachexia. Among different intracellular proteolytic pathways, the energy-ubiquitindependent pathway is particularly important ...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1954
ISSN: 0035-9157
DOI: 10.1177/003591575404700113